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We have compared the response of the N-methyl-N-nitrosourea-induced rat mammary tumor to various endocrine agents with response in patients with breast cancer. To do this, we have induced tumors in 228 animals (65% of intact rats developed tumors but only 14% of ovariectomized rats developed tumors). In intact rats, 4-hydroxyandrostenedione, tamoxifen, and a combination of tamoxifen, aminoglute...
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Primary and secondary malignant central nervous system (CNS) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. Glioblastoma multiform (GBM), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced DNA damage repair program that also induces recurrence and resists current chemo- and radi...
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In 1890, Coley observed that cancer patients who developed infections had smaller tumors. From this, he developed Coley’s toxin and treated tumors with injections of infectious materials. In 1960s, Mahaley used monoclonal antibodies to treat central nervous system(CNS) tumors, that research and clinical investigations in brain tumor immunotherapy became a serious undertaking. ...
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1Department of Pharmacology and Experimental Therapeutic and the Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA 2Department of Psychobiology, Universidade Federal de São Paulo, 04024-002 São Paulo, SP, Brazil 3Department of Anatomy & Neurobiology, Dalhousie University, Halifax, NS, Canada B3H 4R2 4Department of Psychiatry, University of California, ...
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ژورنال
عنوان ژورنال: Neurologia medico-chirurgica
سال: 1961
ISSN: 0470-8105,1349-8029
DOI: 10.2176/nmc.3.206a